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Zepbound (for weight management and obstructive sleep apnea) and Mounjaro (for type 2 diabetes) are both made by Eli Lilly, FDA-approved, and tested for purity, strength, and sterility

340,341,342 The increased expression of miR-195-5p also significantly reduces the expression of Cldn2, increases the expression of tight junction proteins, and increases the permeability of the intestinal barrier

However, there have been relatively few studies on the mechanism of GLP-1RAs in the treatment of chronic pain