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Finally, the causal relationship between iron overload and lipid peroxidation in pathological contexts is often assumed rather than rigorously validated, with limited understanding of how other cellular stressors (e.g., metabolic reprogramming and extracellular matrix remodeling) modulate this core axis

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These include: Medullary thyroid carcinoma (MTC): Retatrutide is contraindicated in individuals with personal or family history of thyroid cancer, such as medullary thyroid cancer or Multiple endocrine neoplasia syndrome type 2 (MEN 2), because this medication can increase the risk of thyroid C-cell tumors