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The primary concern is irritation , destabilization or reduced efficacy if paired with very low pH actives or aggressive exfoliants

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doi:10.1007/s40005-020-00482-z 113

Generally Safe For: Healthy adults above 18 People dealing with dull or uneven skin tone Individuals with post-acne pigmentation Men and women seeking gradual skin brightening Adults exposed to pollution and sun damage Users not taking prescription medications People Who Should Consult a Doctor First Pregnancy & Breastfeeding There is limited research on glutathione supplementation during pregnancy and breastfeeding, so medical guidance is recommended