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In current clinical practice, vitamin E is the most commonly used medication, though evidence of efficacy is limited in those with diabetes and cirrhosis and current AASLD and EASL guidelines recommend its use be restricted to patients with NASH in the absence of diabetes and cirrhosis.[23], [24] This recommendation is largely based on data from the PIVENS trial where subjects randomised to 800 IU/day of vitamin E for 96 weeks demonstrated improvements in steatosis (p = 0.005), lobular inflammation (p = 0.02) and ballooning (p = 0.01), as well as resolution of NASH (43% vs

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Other studies have reported effects on overall growth of the pancreas (as opposed to islet growth) or evidence of increased exocrine mitogenesis