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This gap is normal

Ozempic works by mimicking the action of the hormone GLP-1, which regulates appetite, food intake, and glucose metabolism

Despite a better side effect profile, dronedarone is less effective than amiodarone in rhythm control and is contraindicated in clients with heart failure or permanent AF due to increased mortality (11)(21)(40)

BMJ Disease Reviews Finally, a systematic review and meta-analysis in JAMA Neurology (2025) pooling randomized cardiometabolic trials found no overall cognitive/dementia benefit across all cardioprotective diabetes drugs , but GLP-1 RAs stood out with a statistically significant reduction in incident dementia in subgroup analysesimportant but still Can GLP-1 Drugs Help Prevent Dementia