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In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids. Incretin hormones are released whenever food is consumed

If approved, OAV101IT could provide an alternative to IV-administered onasemnogene abeparvovec (Zolgensma) for the treatment of SMA, particularly for patients who may not qualify for IV administration due to weight restrictions

While semaglutide with B12 is a game-changer for managing hunger, it shines brightest when it's part of a bigger picture of healthy living

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