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In DFO-treated parasites, while some overlap with DHA-induced genes (e.g., merozoite-related functions) was observed at later stages, unique transcriptional changes were also evident, such as upregulation of genes involved in chromatin organization, protein-DNA complex assembly, nucleosome dynamics, regulation of RNA polymerase II-mediated transcription initiation, and regulation of protein catabolic processes

The FDA began allowing the distribution of compounded semaglutide and tirzepatide when both drugs were initially placed on the agencys drug shortage list in 2022