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This is may be the reason why hyaluronic acid is mostly used in products that promises to treat wrinkles

Natural products appear to exert modulatory effects on this system, either by activating protective autophagy to clear damaged organelles and reduce oxidative load, or by inhibiting excessive autophagy to prevent unnecessary cellular degradation

Ashwagandha ( Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic factor pathway under unexpected chronic mild stress

The study found increased oxidative stress, abnormal mitochondrial morphology, and impaired mitochondrial homeostasis in these neurons [97]