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Bulk RNA-Seq data for 449 COAD samples were retrieved from the TCGA-COAD cohort ( while clinical and pathological information was obtained from UCSC Xena ( In this study, samples lacking complete clinical pathological data or with survival times of less than 1 month were excluded

If anaphylaxis or angioedema occurs, the medication should be discontinued permanently and not restarted

However, under certain pathological conditions, excessive changes in organ weight due to organ congestion and oedema, hyperplasia and hypertrophy, atrophy or degeneration will occur