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Side Effects and Safety Side effects Across preclinical studies and the small human trials published to date (~28 subjects across pilot studies), the reported adverse events stay limited: Mild injection-site irritation (rare) No systemic toxicity at therapeutic doses in published reports Oral administration: mild GI upset in sensitive individuals No immunosuppression, hormonal disruption, or metabolic side effects have been observed

The addition of methotrexate or another DMARD may also be considered for patients with an inadequate response, although as previously noted, there is little evidence to suggest that methotrexate provides synergistic efficacy in PsA as opposed to RA

This effect is particularly important for: Wound healing Tendon and ligament repair (notoriously poor blood supply) Cardiac tissue recovery Gastrointestinal mucosal regeneration EGF (Epidermal Growth Factor) EGF promotes cell proliferation and differentiation, particularly in epithelial tissues

The formulation differs fundamentally from Mounjaro or Zepbound, the FDA-approved brand versions