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Injection site nodules or persistent induration lasting beyond one week may indicate lipohypertrophy, sterile abscess formation, or rarely, localized inflammatory reactions

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192 Additionally, mRNA therapy has been applied to treat patients with deficiencies in essential enzyme genes, such as argininosuccinate lyase, ornithine transcarbamylase, and methylmalonyl-CoA mutase (MUT), therefore restoring enzyme levels and mitigating deficiencies