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The first uptake is of glutamate and GABA into astrocytes, where a large fraction is converted to glutamine in an energy-requiring process, and the second uptake is that of glutamine into neurons

Furthermore, during the preclinical development of senkyunolide-based therapeutics, high-throughput screening technologies can be utilized to systematically profile their activity against common receptors, ion channels, and key enzyme systems, thereby predicting potential off-target pharmacological effects

Effects of cognitive behavioural therapy on insomnia in adults with tinnitus: Systematic review and meta-analysis of randomised controlled trials

Chung A, Langdom R