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Our literature review indicated that the effect of vasoconstriction is closely associated with elevated calcium concentration

This is further broken down into an earlier component, the mechanoreflex: brought about by mechanical stretch of the muscles and tendons, followed by the metaboreflex: formed by the buildup of metabolites such as lactic acid, prostaglandins, bradykinin, and hydrogen ions within the muscle

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Reference: MOTSCDPEN10 MOTS-C Disposable Pen MOTS-C (Mitochondrial open reading frame of the 12S rRNA-c) is a peptide encoded in mitochondrial DNA