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Alteration of gut microbiota in individuals at high-risk for rheumatoid arthritis associated with disturbed metabolome and the initiation of arthritis through the triggering of mucosal immunity imbalance

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While GIP indeed acts as an incretin in healthy individuals, researchers found an important limitation in patients with type 2 diabetes, GIP loses most of its insulinotropic efficacy (the pancreatic cells become GIP-resistant) ( [32] )