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The SURMOUNT-5 trial (Aronne LJ et al., N Engl J Med

PT-141 10 mg $45.00 Overview PT-141 (bremelanotide) is a melanocortin receptor agonist that directly activates brain pathways for sexual desire and arousal, delivering reliable, on-demand erections in men and heightened libido plus genital sensitivity in women, independent of vascular mechanisms

Genetic mutations that inhibit MC4R signaling cause hyperphagia, decreased energy expenditure, and early-onset severe obesity, demonstrating the receptor's fundamental importance in weight regulation