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10.1016/j.cmet.2006.01.004 25 DruckerD

The ER-resident GPx7 or GPx8 isoforms protect -cells of insulin-secreting INS against lipotoxicity by enhancing the antioxidant capacity of ER without compromising insulin production and oxidative protein folding mechanisms [19, 59]

2007 Jun 1

Positioning in guidelines In the NICE NG28 guideline, 3 the DPP-4 inhibitors may be used first-line when metformin is contraindicated or not tolerated