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Several CYP enzymes in human microsomes and cDNA-expressed human P450 isoforms, including CYP2D6, CYP2C9, CYP2B6, CYP2C19 and CYP3A4, contribute to sertraline N -demethylation

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Eligible studies had to present original data demonstrating sertraline's impact on cancerrelated outcomes, such as cell viability, apoptosis, or tumor regression

Kaempferol-3-O-rutinoside exhibits strong binding to the essential MmpL3 transporter, supporting its further experimental development as a therapeutic applicant (69)