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Quick Answer: Semaglutide is associated with an increased risk of gallstone formation, with clinical trials showing cholelithiasis occurring in approximately 1.6% of treated patients compared to 0.7% receiving placebo

Diabetes Obes Metab 18(4):317332 Madsen LW, Knauf JA, Gotfredsen C, Pilling A, Sjgren I, Andersen S et al (2012) GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation

When they simply eat a smaller volume of the same foods, their insulin may come down some, but often not enough to open the fat stores efficiently

Atypical femur fractures can present as insidious-onset pain in the subtrochanteric region before any fracture has occurred on imaging