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Since kidney function is reduced during AKI, activation of the urea cycle and subsequent urea generation together lead to a substantial rise in BUN 14,35

Role of the Methionine Cycle in Epigenetics The role of methionine synthesis and regeneration, via the methionine cycle, in the methylation of DNA and histones, events that are central to epigenetic regulation of gene expression, is evident from the fact that this process is required for the synthesis of S-adenosylmethionine (SAM)

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[PubMed] [Google Scholar] 64.Werling DM, Geschwind DH