pharma news today obesity drugs glp-1 october 2025 Alarming rise in weight loss drug overdoses Anti-Obesity Medications Set to Explode

I was obese

Several pathophysiologic mechanisms have been postulated, such as autonomic abnormalities, hypothalamic-pituitary-adrenal (HPA) activation, genetic abnormalities, neuronal hyperexcitability, and gastric dysmotility

Ridha Z et al, Aesthetic Surgery Journal 44(11):NP809-NP818, PMID 38874170) describes GLP-1 receptors on adipose-derived stem cells (ADSCs) and fibroblasts in skin, and proposes that activation of these receptors may reduce protective cytokine production from ADSCs, increase oxidative stress on neighboring fibroblasts, reduce ATP production through altered glucose uptake, and indirectly reduce local estrogen production from dermal white adipose tissue

PMID 3800996