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While C-reactive protein (CRP) is the most established systemic inflammatory CV risk marker, recent data indicate that inflammatory markers in vascular tissue [matrix metalloproteinases (MMP), osteopontin (OPN), and cathepsin D] may be more specific measures of plaque instability (239)

Maximum dose: 400 mg per day, given as 200 mg twice daily , for those not responding to 300 mg/day

[1] In the SURMOUNT-1 clinical trial, higher doses in non-diabetic adults demonstrated significant weight loss, with participants losing approximately 15-20% of body weight over 72 weeks