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Appendices Appendix 1: Literature Search Strategies Literature Search - Vitamin B12 Economic Evidence-Based Analysis Search date: June 3, 2013 Databases searched: OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE

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In fact, one clinical study comparing the same amount of B-12 given orally or under the tongue found they were equally effective at correcting B-12 deficiency over a two-month period

Research has reported that blocking NNMT was associated with increased energy expenditure and reduced fat mass in animal studies, independent of diet or exercise changes