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Active Ingredient Semaglutide (Intermediate GLP-1 Agonist) Total Strength per Vial 1 mg Semaglutide solution Dose Classification Intermediate Titration / Step-Up Tier Primary Manufacturer Glenmark Pharmaceuticals Ltd Therapeutic Class Incretin Mimetic / Antidiabetic / Anti-Obesity Administration Route Subcutaneous Injection (Weekly calibrated dose) Supply Format 1 Multi-dose Vial / Pen System

( h ) Percentage of transient responders out of the total number of semaglutide responsive cells per slice from Wildtype (black, n = 6 slices, 4 mice, 2 males) mice or Barr1/2 fl/fl (purple, n = 6 slices, 3 mice, 2 males) mice

Taste receptor cells generate oscillating receptor potentials by activating G protein-coupled taste receptors