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Weight loss from Linzess is typically rapid, occurs in the first week or two of treatment, and then plateaus

It binds a distinct receptor population on somatotrophs via a phospholipase C / IP3 intracellular pathway separate from the cAMP route used by GHRH

The long half-life means you still have circulating cagrilintide even several days after a missed dose, though at reduced levels

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