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Understanding common side effects 1 The most common adverse reactions, reported in 5% of patients treated with RYBELSUS are: nausea abdominal pain diarrhea decreased appetite vomiting constipation In the pool of placebo-controlled trials, the majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation

The drug negatively impacted the absorption of oral hormonal contraceptives, especially right after starting tirzepatide or following a dose increase, more than semaglutide or liraglutide

It is hard to predict who will be able to tolerate them and who wont, she said, although people who already struggle with gastrointestinal health issues may find these medications make them worse. Garcia-Webb added that clinically, she does find that people often have fewer side effects on Mounjaro than on Wegovy

As more states have legalized the substance, the research into its medical uses has expanded exponentially