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Starting dose Zepbound is started at a lower dose of 2.5 mg once weekly for the first 4 weeks to prevent the risk of gastrointestinal side effects such as nausea and vomiting

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Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

[6] Still, baseline testing may be important if you have a history of liver disease or are taking other medications metabolized by the liver