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Magnitude of Weight Loss GLP-1 medications produce substantially more weight loss than older diabetes treatments: Semaglutide (diabetes doses): Average weight loss of 10-12% of body weight at the 1mg and 2mg doses used for diabetes

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reported that semaglutide accessed the brainstem, hypothalamus, and the dorsal half of the septal area, largely via small circumventricular organs, but it was not shown to cross the BBB [27]