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Lithium, Neurotransmitters, and Receptors Lithium generally influences neurotransmitter systems, balancing excitatory and inhibitory neurotransmitters, increasing GABA/glutamate ratios, and acetylcholine/catecholamine activity to stabilize mood [58] (Fig

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However, these effects are not confined to the intestinal microenvironment, as it has been shown that butyrate produced by gut microbiota induces the expression of mouse -defensin 14 in pancreatic islets, which in turn drives the activation of regulatory macrophages and prevents the development of T1D in a mouse model (130)