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Studies of animal models have shown that such heterozygotes have a higher incidence of cardiomyopathy with aging and may be at risk for cardiac abnormalities when additional cardiac burdens are imposed

After nuclear factor kappa B (NF-kB) activates glutaminase C isoform (GAC), an alternatively spliced isoform of GLS1, via phosphorylation, NF-kB itself is activated by Rho GTPases

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In particular, we substantiated that high levels of Bcl-2 leads to increased amount of GSH and finally impair virus infection ( FIGURE 3 Also other authors have shown the importance of GSH for influenza virus infection and replication