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Lower respiratory tract barriers and low-biomass microbiota The lower respiratory tract (LRT), comprising the trachea, bronchi, and alveoli, harbors bacterial communities with significantly lower abundance and diversity compared to the URT 95,109

Dietary factors, such as polyunsaturated fatty acids (PUFA), fiber as well as the intake of Mediterranean diet appear to exert beneficial effects on female reproductive outcomes

Moreover, gut microbiome and metabolites that have entered the lamina propria may further induce cross-reactive T cell responses or amplify the immune activation state through mechanisms such as molecular mimicry and bystander activation, thereby contributing to the initiation and progression of NIU