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Be aware of red flag symptoms that require immediate medical attention while on these medications: severe or persistent abdominal pain, persistent vomiting/dehydration, jaundice, severe constipation or abdominal distention, vision changes, or signs of hypoglycemia

What is needed is a large, well-designed trial that compares a GLP-1 agonist to placebo in migraine patients, stratified by weight status, migraine subtype, and other relevant variables

On average, the participants were overweight, but a lot slimmer than your average American

In a study using a 2-adrenergic receptor knockout mouse model, etanercept treatment significantly reduced TNF-, SOCS3, and pro-apoptotic protein levels, while increasing phosphorylation of the INSR at tyrosine residues 1150/1151 [372]