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In human FMT or co-housing gallstone-resistant mice, expressions of key enzymes, Hmgcr , Fdps , Sqle , were less inhibited suggesting the maintenance of higher hepatic cholesterol synthesis in these mice even under cholesterol overloading

Inclusion criteria require confirmed UC diagnosis for at least 3 months with active disease extent of 15+ cm from anal verge, moderately to severely active disease defined by mMS 59 with RBS 1 and MES 2, while excluding current CD diagnosis, fulminant colitis requiring surgery, or failure of 4+ advanced therapy classes

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Cardiometabolic improvements also drifted back toward baseline