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This is a meaningful advantage for oral delivery because it partially sidesteps the very gut absorption problems that semaglutide creates

On the other hand, some studies show that taking a high dosage of vitamin B12, such as 1000 mcg, can be an alternative to vitamin B12 injections for those who are lacking the intrinsic factor protein in their diet, or for those with other conditions that do not allow them to absorb their vitamin B12 intake fully

PubMed Heffernan MA et al