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The relationship between muscle mass and weight-loss response can be summarized as a metabolic chain: Muscle mass supports resting metabolic rate Resting metabolic rate influences how many calories the body burns each day Daily calorie burn affects how strongly appetite suppression translates into weight loss Resistance training and adequate protein intake can help support muscle maintenance during weight loss

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Compared with placebo, GLP-1RAs treatment in T2DM patients significantly reduced the risk of death from cardiovascular disease and fatal/non-fatal stroke in cardiovascular outcome trials (Qin and Song, 2022)