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A FAERS-based pharmacovigilance analysis comparing tirzepatide vs semaglutide in female reports (Q1 2022Q3 2025) reported gynaecological haemorrhagic events in 0.62% of semaglutide cases (204 cases among 32,839 female-specific reports in that analysis) and did not detect a disproportionate signal vs tirzepatide

However, theres some concern about semaglutide impacting the effectiveness of birth control pills because of the effects semaglutide has on the digestive system, says Kadaj

Its important for your provider to review your medical history fully before making the switch to tirzepatide

Is bariatric surgery a more appropriate conversation