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Gastrointestinal side effects are the most commonly reported and include: Nausea (affecting 1040% of patients, depending on the specific GLP-1 agonist) Vomiting and diarrhoea (less common than nausea but can contribute to dehydration) Constipation (due to slowed gastric emptying) Abdominal discomfort or bloating These effects are typically most pronounced during treatment initiation and following dose increases

Always wash your hands and keep the injection site clean Wash your hands before you start, and use soap and water or an alcohol swab to clean the injection site

The injection has higher bioavailability, meaning the body absorbs it more easily

Slower titration or temporary dose reduction may be considered if gastrointestinal symptoms are problematic