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This imbalance may be attributed to a decrease in L-Glutamine, Glutaconic acid, L-Glutamic acid, Glutathione, -Glutamylacetamide, -Glutamylcysteine, L-proline, and -Glutamylcysteinylserine

Clinical observations describing reduced protein intake, variability in lean mass trajectories, and micronutrient insufficiency during pharmacologically induced weight loss [40, 75, 94, 95] suggest that long-term metabolic stability may become sensitive to substrate availability even in the absence of overt deficiency

Hence, activated cells shift from an anti-inflammatory and neuroprotective role to one that is pro-inflammatory and neurotoxic