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Because fibre photometry measures population-level activity, we cannot rule out that different subsets of CeA Glp1r neurons are differentially recruited by individual GLP1RAs, with similar bulk responses arising from overlapping but non-identical populations

Experiencing insomnia on GLP-1 is not uncommon, and it can be frustrating when youre trying to improve your overall health

In adults with obesity and knee osteoarthritis, retatrutide delivered: 9mg dose: 26.4% body weight reduction at 68 weeks 12mg dose: 28.7% body weight reduction at 68 weeks (average of 71.2 pounds lost) Placebo: 2.1% body weight reduction The 68-week timeframe is longer than the Phase 2 trial, which partially explains the higher numbers