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At the day 100 of the differentiation of AD organoids, its essential to highlight that the pathology became advanced, potentially leading to severe cell damage due to increase in pathology and the presence of apoptotic bodies

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Data show that, among patients with more advanced hepatic fibrosis (i.e., F3-F4 stages), older age, obesity, thrombocytopenia, and higher GGT activity (transformed in log scale) were independent correlates of the risk for liver-related events (defined as ascites, variceal hemorrhage, encephalopathy, jaundice, or hepatocellular carcinoma) [54]