Functional magnetic resonance imaging in humans demonstrated that peripheral administration of GLP-1 suppresses activity in the hypothalamus, amygdala, insula, and orbitofrontal cortex, thereby decreasing appetite [16]
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Underlying mechanisms contributing to cardiovascular and renal protection are at least partially different between GLP-1RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (mainly systemic and intrarenal hemodynamic changes)
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