Hp cht cng gip tng cng sc bn tp luyn v c phc hi cao hn
Spermidine/spermine N1-acetyltransferase 1 (SSAT) initiates polyamine catabolism, which decreases the cellular content of polyamines through transferring the acetyl group of acetyl-CoA to either spermidine or spermine, which can be oxidized by peroxisomal enzyme polyamine oxidase (PAOX)
One effective solution is the Gibco GlutaMAX Supplement, which contains L-alanyl-L-glutamine, a dipeptide form of L-glutamine
doi: 10.1182/blood.V126.23.3059.3059 Summary Keywords CLL - chronic lymphoblastic leukemia, BTK - Brutons tyrosine kinase, Bcl-2 inhibitor, Mcl-1 inhibitor, ibrutinib, venetoclax, glutamine (Gln) metabolism Citation Timofeeva N, Ayres ML, Baran N, Santiago-OFarrill JM, Bildik G, Lu Z, Konopleva M and Gandhi V (2023) Preclinical investigations of the efficacy of the glutaminase inhibitor CB-839 alone and in combinations in chronic lymphocytic leukemia