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Among them, retatrutide has shown significant clinical advantages in phase II clinical trials, reducing the weight of obese patients by up to 24.2% in 48 weeks and lowering the HbA1c of type 2 diabetes patients by 2.2% in 36 weeks (49, 50)

We would like to acknowledge both Ju Han Lee (graduate student at the University of Florida) and Madison Goetze (undergraduate student at the University of Florida) for their assistance in putting together the tables and editing this manuscript

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Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study