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If vitamin B12 deficiency is not treated with a vitamin B12 supplement, then anemia, intestinal problems, and irreversible nerve damage may occur

But critics fear the FDAs stamp of approval will simply legitimize the use of unproven substances whose dangers may only become apparent in coming years

This has led researchers to explore alternative delivery routes that maximize cellular uptake, stability, and systemic reach, while minimizing degradation

Toxicology Findings Repeated-dose toxicity studies in rats, dogs, and mice for up to 6 weeks across doses from 6 mcg/kg to 20 mg/kg via various routes showed excellent tolerance