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and functio laesa (loss of function)

3.3.1 Gut microbiome dysbiosis in GD induces unbalanced neurotransmitters in the brain Neurotransmitters like serotonin [also known as 5-hydroxytryptamine (5-HT), dopamine (DA), and noradrenaline (NE)] have been implicated in the pathophysiology of depression for many years as essential components of the brains function

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However, more recent data show that fasting hyperhomocysteinemia defined with a lower cut-off value (12 mol/L) is associated with increased odds ratios for atherosclerotic vascular diseases (see Hyperhomocysteinemia and Vascular Pathologies) (Graham et al, 1997)