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Key Points Tirzepatide (Mounjaro/Zepbound) works differently than semaglutide (Ozempic/Wegovy) by targeting two hormones instead of one Studies show tirzepatide typically leads to greater weight loss (15-20% vs 8-10%) and better blood sugar control than semaglutide Switching is generally straightforward you can finish your semaglutide dose and start tirzepatide about a week later on your normal dose day Most people start at a lower tirzepatide dose (2.5mg or 5mg) even if they were on a high dose of semaglutide Thinking about making the switch from semaglutide (Ozempic or Wegovy) to tirzepatide (Mounjaro or Zepbound)