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Key factors influencing cost include: Regulatory status: Licensed medicines that have undergone full MHRA or EMA approval typically command higher prices than older, off-patent alternatives, reflecting the investment in clinical development and post-marketing surveillance

81,82 A meta-analysis of 15 studies with a total of 7,466 men found genetic mutations (commonly known as single nucleotide polymorphisms or SNPs [pronounced snips]) affecting the methylenetetrahydrofolate reductase (MTHFR) gene that regulates folate metabolism were associated with an increased risk of male infertility