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Studies in populations with selenium deficiency show higher event rates, reversible with supplementation

These interdisciplinary approaches are expected to reveal novel biomarkers that can predict cellular senescence and the aging trajectory, as well as therapeutic targets for interventions aimed at reversing senescence in tissues

Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits