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Mounjaro (tirzepatide) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK specifically for the treatment of type 2 diabetes mellitus

5.4 Gastrointestinal Side Effects and Nutrient Loss Nausea and vomiting are well-documented adverse effects. Persistent vomiting or diarrhoea may: Increase electrolyte loss Reduce caloric intake Reduce dietary diversity However: These effects are typically transient and dose-related

PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP1 receptor agonistinduced tachycardia in mice

Whilst many skin reactions are benign and resolve without intervention, some may require assessment to rule out more serious allergic reactions or other underlying causes