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MacDonald PE, El-Kholy W, Riedel MJ, et al

While tirzepatide can be taken with or without food, some patients find that administering the injection before a meal helps them remember their dose, while others prefer dosing at a time unrelated to eating to avoid potential nausea associations

That growth hormone then has widespread effects, including some fat-burning activity

Nausea sits at the top of the list, usually mild, usually concentrated in the first few weeks after a dose increase, and usually fading as the body adjusts