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These converge on two outcomes critical to capillary formation: endothelial cell proliferation (driven primarily by ERK1/2 activation) and endothelial cell survival and migration (driven primarily by Akt phosphorylation)

This synergy is under exploration in models studying aging, metabolic health, and endurance performance

Agmatine and sleep While Agm has been studied in the context of sleep-adjacent phenomena, such as enhanced anti-convulsant effects when Agm is co-delivered with the sleep-promoting indolamine melatonin (Moezi et al., 2011), I was unable to locate studies of Agm in the context of sleep per se , let alone its potential roles as a co-transmitter in this context

Ding, X., Kakanj, P., Leptin, M., & Eming, S